This is the list of Schedule II drugs as defined by the United StatesControlled Substances Act.[1]The following findings are required for drugs to be placed in this schedule:[2]
Adobe premiere pro cs4 free download - Adobe Illustrator, Adobe Creative Cloud, Adobe Premiere Pro CS5.5, and many more programs. Adobe Premiere Pro CS4 Free Download Latest Version for Windows. It is full offline installer standalone setup of Adobe Premiere Pro CS4 for 32/64 Bit. Adobe Premiere Pro CS4 Overview. Adobe Premiere Pro is the oldest video editing application for PC platform. Premiere Pro has got a very illustrious history when it comes to video editing. Thank you for purchasing an Adobe Creative Suite 4 product! Installation is quick and easy. If you purchased a retail licensed CS4 product and no longer have the installation media, you can download replacement installers from this page. Adobe premiere cs4 download. Adobe Premiere Pro CS4 Download Free Latest Version for Windows. It is full offline installer standalone setup of Adobe Premiere Pro CS4 Download for 32/64. Adobe Premiere Pro CS4 Overview. Adobe Premiere Pro is an imposing video editing application which can be used for enhancing the videos professionally.
- The drug or other substance has a high potential for abuse.
- The drug or other substance has a currently accepted medical use in treatment in the United States or a currently accepted medical use with severe restrictions.
- Abuse of the drug or other substances may lead to severe psychological or physical dependence.
The complete list of Schedule II drugs follows.[1] The Administrative Controlled Substances Code Number for each drug is included.
A great place to find Marathi Movies, full movie download, free movie download, free bollywood movie download, hd mobile movies, full hd movie download. Coolmoviez is the website of movie freak who wants to download latest trending movie in the movie industry. Onlinesream is know for its unique content that’s why before. Latest marathi movie free download. New Marathi Full Movies (2017) Download, Latest Marathi Full Movies (2017) Free Download, Marathi Full Movies (2017) 3gp Mp4 HD Avi Mkv Quality - Latest 2018 Hindi Punjabi Hollywood And All Language Full HD Movies. Latest Marathi Full Movies Download, Marathi Full HD Movies 300mb, Marathi Mkv Moviez, Marathi HD 480p 720p 1080p Pc Movies Free Download Mp4Moviez Filmywap Bollywood Hindi Movies. You can get facility to download free latest Marathi in different size with HD format, hdfriday provides you latest Marathi 2019 on daily bases page 1. Marathi movies download, marathi movies 300mb, marathi movies 3gp free download, marathi movies 2015 download, marathi movies full download free, marathi movies full hd video, marathi full movie, marathi watch movies, marathi 300mb movies. DON’T MISS LATEST UPDATE MOVIES. Enter your email address: Delivered by FeedBurner. Recent Posts.
Logic pro x cracked download. • Elimination of various categories through the Plug-in Manager. System Requirements: OS: macOS 10.12 or later. • New Closing project in full-screen mode. Graphics Card: OpenCL-capable graphics card or Intel HD Graphics 3000 or later. • Different Looping through the cycle.
| ACSCN | Class | Drug |
|---|---|---|
| 9050 | opiate | Codeine |
| 9334 | opiate | Dihydroetorphine |
| 9190 | opiate | Ethylmorphine |
| 9059 | opiate | Etorphine hydrochloride |
| 9640 | opiate | Granulated opium |
| 9193 | opiate | Hydrocodone |
| 9150 | opiate | Hydromorphone |
| 9260 | opiate | Metopon |
| 9300 | opiate | Morphine |
| 9610 | opiate | Opium extracts |
| 9620 | opiate | Opium fluid |
| 9330 | opiate | Oripavine |
| 9143 | opiate | Oxycodone |
| 9652 | opiate | Oxymorphone |
| 9639 | opiate | Powdered opium |
| 9600 | opiate | Raw opium |
| 9333 | opiate | Thebaine |
| 9630 | opiate | Tincture of opium |
| opiate | Opium poppy and poppy straw | |
| 9040 | stimulant | Coca, leaves and any salt, compound, derivative or preparation of coca leaves |
| 9041 | stimulant | Cocaine, and its salts, isomers, derivatives and salts of isomers and derivatives |
| 9180 | stimulant | Ecgonine, and its salts, isomers, derivatives and salts of isomers and derivatives |
| 9670 | opiate | Concentrate of poppy straw (the crude extract of poppy straw in either liquid, solid or powder form which contains the phenanthrene alkaloids of the opium poppy) |
| 9737 | opioid | Alfentanil |
| 9010 | opiate | Alphaprodine |
| 9020 | opioid | Anileridine |
| 9800 | opiate | Bezitramide |
| 9273 | opioid | Bulk dextropropoxyphene (non-dosage forms) |
| 9743 | opioid | Carfentanil |
| 9120 | opiate | Dihydrocodeine |
| 9170 | opioid | Diphenoxylate |
| 9801 | opioid | Fentanyl |
| 9226 | opioid | Isomethadone |
| 9648 | opiate | Levo-alphacetylmethadol |
| 9210 | opiate | Levomethorphan |
| 9220 | opiate | Levorphanol |
| 9240 | opioid | Metazocine |
| 9250 | opioid | Methadone |
| 9254 | opiate intermediate | Methadone intermediate: 4-cyano-2-dimethylamino-4,4-diphenyl butane |
| 9802 | opiate intermediate | Moramide intermediate: 2-methyl-3-morpholino-1,1-diphenylpropane-carboxylic acid |
| 9230 | opioid | Pethidine (meperidine) |
| 9232 | opiate intermediate | Pethidine intermediate A: 4-cyano-1-methyl-4-phenylpiperidine |
| 9233 | opiate intermediate | Pethidine intermediate B, ethyl-4-phenylpiperidine-4-carboxylate |
| 9234 | opiate intermediate | Pethidine intermediate C, 1-methyl-4-phenylpiperidine-4-carboxylic acid |
| 9715 | opiate | Phenazocine |
| 9730 | opiate | Piminodine |
| 9732 | opiate | Racemethorphan |
| 9733 | opiate | Racemorphan |
| 9739 | opiate | Remifentanil |
| 9740 | opiate | Sufentanil |
| 9780 | opiate | Tapentadol |
| 1100 | stimulant | Amphetamine, its salts, optical isomers, and salts of its optical isomers (Adderall) |
| 1105 | stimulant | Methamphetamine, its salts, isomers, and salts of its isomers |
| 1631 | stimulant | Phenmetrazine and its salts |
| 1724 | stimulant | Methylphenidate (Ritalin, Concerta, etc.) |
| 1205 | stimulant | Lisdexamfetamine (Vyvanse), its salts, isomers, and salts of its isomers |
| 2125 | depressant | Amobarbital |
| 2550 | depressant | Glutethimide |
| 2270 | depressant | Pentobarbital |
| 7471 | depressant | Phencyclidine |
| 2315 | depressant | Secobarbital |
| 7379 | hallucinogen | Nabilone |
| 8501 | precursor | Phenylacetone |
| 7460 | precursor | 1-phenylcyclohexylamine |
| 8603 | precursor | 1-piperidinocyclohexanecarbonitrile (PCC) |
| 8333 | precursor | 4-anilino-N-phenethyl-4-piperidine (ANPP) |
References[edit]
- ^ ab21 CFR1308.12 (CSA Sched II) with changes through 77 FR64032 (Oct 18, 2012). Retrieved September 6, 2013.
- ^21 U.S.C.§ 812(b)(4) retrieved October 7, 2007
The Biopharmaceutics Classification System is a system to differentiate the drugs on the basis of their solubility and permeability.[1]
This system restricts the prediction using the parameters solubility and intestinal permeability. The solubility classification is based on a United States Pharmacopoeia (USP) aperture. The intestinal permeability classification is based on a comparison to the intravenous injection. All those factors are highly important because 85% of the most sold drugs in the United States and Europe are orally administered[citation needed].
BCS classes[edit]
According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability:[1]
- Class I - high permeability, high solubility
- Example: metoprolol, paracetamol[2]
- Those compounds are well absorbed and their absorption rate is usually higher than excretion.
- Class II - high permeability, low solubility
- Example: glibenclamide, bicalutamide, ezetimibe, aceclofenac
- The bioavailability of those products is limited by their solvation rate. A correlation between the in vivo bioavailability and the in vitro solvation can be found.
- Class III - low permeability, high solubility
- Example: cimetidine
- The absorption is limited by the permeation rate but the drug is solvated very fast. If the formulation does not change the permeability or gastro-intestinal duration time, then class I criteria can be applied.
- Class IV - low permeability, low solubility
- Example: Bifonazole
- Those compounds have a poor bioavailability. Usually they are not well absorbed over the intestinal mucosa and a high variability is expected.
Definitions[edit]
The drugs are classified in BCS on the basis of solubility, permeability, and dissolution.
Solubility class boundaries are based on the highest dose strength of an immediate release product. A drug is considered highly soluble when the highest dose strength is soluble in 250 ml or less of aqueous media over the pH range of 1 to 7.5. The volume estimate of 250 ml is derived from typical bioequivalence study protocols that prescribe administration of a drug product to fasting human volunteers with a glass of water.
Permeability class boundaries are based indirectly on the extent of absorption of a drug substance in humans and directly on the measurement of rates of mass transfer across human intestinal membrane. Alternatively non-human systems capable of predicting drug absorption in humans can be used (such as in-vitro culture methods). A drug substance is considered highly permeable when the extent of absorption in humans is determined to be 90% or more of the administered dose based on a mass-balance determination or in comparison to an intravenous dose.
For dissolution class boundaries, an immediate release product is considered rapidly dissolving when no less than 85% of the labeled amount of the drug substance dissolves within 15 minutes using USP Dissolution Apparatus 1 at 100 RPM or Apparatus 2 at 50 RPM in a volume of 900 ml or less in the following media: 0.1 N HCl or simulated gastric fluid or pH 4.5 buffer and pH 6.8 buffer or simulated intestinal fluid.
See also[edit]
- ADME
References[edit]
- ^ abMehta M (2016). Biopharmaceutics Classification System (BCS): Development, Implementation, and Growth. Wiley. ISBN978-1-118-47661-1.
- ^https://www.ema.europa.eu/documents/scientific-guideline/draft-paracetamol-oral-use-immediate-release-formulations-product-specific-bioequivalence-guidance_en.pdf
Further reading[edit]
- Folkers G, van de Waterbeemd H, Lennernäs H, Artursson P, Mannhold R, Kubinyi H (2003). Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability (Methods and Principles in Medicinal Chemistry). Weinheim: Wiley-VCH. ISBN3-527-30438-X.
- Amidon GL, Lennernäs H, Shah VP, Crison JR (March 1995). 'A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability'. Pharm. Res. 12 (3): 413–20. PMID7617530.
External links[edit]
- BCS guidance of the U.S. Food and Drug Administration